High-Throughput Optimization of Ir-Catalyzed C–H

Iron-Catalysed C(sp2)-H Borylation Enabled by Carboxylate Arene C(sp2)-H bond borylation reactions provide rapid and efficient routes to synthetically versatile boronic esters. While iridium catalysts are well established for this reaction, the discovery and development of methods using Earth-abundant alternatives is limited to just a few examples. Applying an in situ catalyst activation method using air-stable and easily handed reagents, the iron Molecules | Free Full-Text | Weinreb Amides as Directing Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific

Abstract. A ligand-controlled discovery of ortho and meta C–H boryl­ation of aromatic aldehydes is described. In both cases, an amine is used and it was proposed that ortho borylation could be realized using tert-butylamine as the traceless protecting/directing group and meta boryl­ation undergoes via an electrostatic interaction and a secondary interaction between the ligand of the

A Traceless Directing Group for C H Borylation. Angewandte Chemie International Edition 2013 , 52 (49) , 12915-12919. DOI: 10.1002/anie.201306511. A traceless directing group for C-H borylation. Angew Chem Int Ed Engl . 2013; 52(49): 12915-12919. doi: 10.1002/anie.201306511 Kuninobu Y, Ohmura T, Iwanaga T, Takai K. Palladium-catalyzed ortho selective C-H borylation of 2-phenylpyridine and its derivatives at room temperature .

Protodeboronation - Organic Chemistry

Boron-mediated directed aromatic C–H hydroxylation