High-Throughput Optimization of Ir-Catalyzed C–H
Iron-Catalysed C(sp2)-H Borylation Enabled by Carboxylate Arene C(sp2)-H bond borylation reactions provide rapid and efficient routes to synthetically versatile boronic esters. While iridium catalysts are well established for this reaction, the discovery and development of methods using Earth-abundant alternatives is limited to just a few examples. Applying an in situ catalyst activation method using air-stable and easily handed reagents, the iron Molecules | Free Full-Text | Weinreb Amides as Directing Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific
Abstract. A ligand-controlled discovery of ortho and meta C–H borylation of aromatic aldehydes is described. In both cases, an amine is used and it was proposed that ortho borylation could be realized using tert-butylamine as the traceless protecting/directing group and meta borylation undergoes via an electrostatic interaction and a secondary interaction between the ligand of the
A Traceless Directing Group for C H Borylation. Angewandte Chemie International Edition 2013 , 52 (49) , 12915-12919. DOI: 10.1002/anie.201306511. A traceless directing group for C-H borylation. Angew Chem Int Ed Engl . 2013; 52(49): 12915-12919. doi: 10.1002/anie.201306511 Kuninobu Y, Ohmura T, Iwanaga T, Takai K. Palladium-catalyzed ortho selective C-H borylation of 2-phenylpyridine and its derivatives at room temperature .
Protodeboronation - Organic Chemistry
Boron-mediated directed aromatic C–H hydroxylation